MKK7 transcription positively or negatively regulated by SP1 and KLF5 depends on HDAC4 activity in glioma
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CD99 expression is positively regulated by Sp1 and is negatively regulated by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) is highly expressed in Hodgkin and Reed-Sternberg (H-RS) cells from patients with EBV-associated Hodgkin disease. It was previously demonstrated that CD99 can be negatively regulated by LMP1 at the transcriptional level, and the decreased expression of CD99 in a B lymphocyte cell line generates H-RS-like cells. In this study, det...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2019
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.32321